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Organoid-Based Drug Screening Platform: High-Throughput Analysis of Cardiac Toxicity in Human Heart Organoids

ID:

001515

DRAFT

Contact: Silkuniene, Giedre

File Count: 292

Size: 7 GiB

Created: June 27, 2025

Last update: July 16, 2025

Licenses: spdx:CC-BY-4.0

Access Information: dandi:OpenAccess

This comprehensive study investigated drug-induced cardiotoxicity using human iPSC-derived heart organoids. We developed a high-throughput screening platform to assess the effects of 200+ pharmaceutical compounds on cardiac function, including contractility, electrophysiology, and cellular viability over 14-day treatment periods.

Contributors

Dr. Elena Vasquez, Organoid Systems Lab

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Funding information

National Institutes of Health - Organoid Initiative

- Award Number: 1R01GM145892

Organoid Summary

Organoid Type

Cardiac Organoids - Human iPSC-derived

Data Standard

Organoid Intelligence Standard (OIS)

RRID:SCR_025847

Number Of Organoids

156

Associated Projects

Organoid Intelligence Consortium - Cardiac Function Modeling

Identifier: OIC-2025-CARDIAC-001