# Comprehensive analysis of brain organoid development in Alzheimer's disease ## Overview This dataset provides detailed characterization of brain organoids derived from patient iPSCs with familial Alzheimer's disease mutations. We tracked organoid development over 180 days, measuring synaptic activity, protein aggregation, and transcriptomic changes. The study includes organoids from 12 patient lines and 8 control lines, with multi-electrode array recordings, immunofluorescence imaging, and single-cell RNA sequencing data.
Sarah Chen and Michael Rodriguez and Elena Petrov and James Kim and Lisa Zhang and David Thompson (2025). Brain Organoid Development and Synaptic Activity Patterns in Alzheimer's Disease Models. OpenNeuro. [Dataset] doi:10.18112/openorganoid.ds006472.v1.0.0
Comprehensive multi-organ system modeling drug metabolism and toxicity pathways across interconnected liver, heart, and kidney organoids over 30-day culture periods.
Dr. Amanda Foster and Prof. Robert Chen and Dr. Maria Santos (2025). Multi-Organ-on-Chip: Liver-Heart-Kidney Interaction Studies. OpenNeuro. [Dataset] doi:10.18112/openorganoid.ds006466.v1.0.0
This groundbreaking dataset explores learning capabilities in brain organoids through electrical stimulation protocols. We demonstrate memory formation and recall in 3D brain tissue cultures using novel training paradigms and multi-electrode array recordings over 6-month periods.
Dr. Jennifer Walsh and Prof. Alex Kumar and Dr. Sophie Martinez (2025). Organoid Intelligence: Learning and Memory Formation in Brain Organoids. OpenNeuro. [Dataset] doi:10.18112/openorganoid.ds006462.v1.0.1